In June 2017 KCE Trials was delighted to welcome Professor Sandra Eldridge (Professor of Biostatistics; Director, Pragmatic Clinical Trials Unit, Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University of London, UK) to KCE to give a talk on pragmatic trials. This focused on an introduction, some issues, and emerging designs. She also did a Q&A where she gave short answers on many key questions in pragmatic trials. Her talk and Q&A can be viewed via the links below.
Presentation:
Part 1: Introduction to pragmatic trials (25 mins)
Part 2: Introduction to pragmatic trials continued (25 mins)
Part 3: Cluster randomised trials and stepped wedge designs (22 mins – 16 talk and 6 minutes questions)
Q&A (answers 2-5 minutes) quoted references are given at the end of each clip
- What is a pragmatic trial?
- How are pragmatic trials different from the usual kind of development/explanatory trial?
- How should pragmatic trials be conducted?
- What about the intervention, how should I describe it?
- What are typical endpoints for pragmatic trials?
- What about bias and blinding?
- How can I get an idea of how pragmatic or how explanatory my planned trial is?
- What is the PRECIS-2 tool?
- Where can I get more information about pragmatic trials?
- What is a cluster-randomised trial and when is it useful?
- How do you handle informed consent in cluster-randomised trials?
