Resources for investigators

Useful documents for investigators

To optimise the chance for a successful application, read the top 10 tips and tricks here.

Each call has its own specific forms and documents to be used. Here you can find the forms and for the 2017 investigator-led call:

Additional information:

Useful links on pragmatic trials

Pragmatic trials are trials that are designed to compare treatment options in a real-world setting, as opposed to explanatory trials that test a physiological or clinical hypothesis, typically to develop new drugs or other treatments. Trials can be pragmatic with regards to several features, such as the way sites and patients are recruited, the choice of outcomes, the interventions and their delivery etc.  

This NEJM paper gives more information on pragmatic trials: http://www.nejm.org/doi/full/10.1056/NEJMra1510059

The PRECIS (Pragmatic-Explanatory Continuum Indicator Summary) is a tool to help trialists designing clinical trials consider where they would like their trial to be on the pragmatic or explanatory continuum. It can be found here: https://www.precis-2.org/

The authors of the GetReal consortium (workpackage 3) have a series of interesting publications on pragmatic trials:

Presentation on pragmatic trials by Professor Sandra Eldridge

In June 2017 KCE Trials was delighted to welcome Professor Sandra Eldridge (Professor of Biostatistics; Director, Pragmatic Clinical Trials Unit, Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University of London, UK) to KCE to give a talk on pragmatic trials. This focused on an introduction, some issues, and emerging designs. She also did a Q&A where she gave short answers on many key questions in pragmatic trials. Her talk and Q&A can be viewed via the link below.

Other resources

DELTA2 Guidance – Difference Elicitation in trials https://www.csm.ox.ac.uk/research/methodology-research/delta2  

Published on: 
20-11-2017