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melanome

NEW PHARMACEUTICALS FOR UNRESECTABLE OR METASTATIC MALIGNANT MELANOMA

This KCE has read for you was prepared by Lorena San Miguel and Nadia Benahmed

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KEY MESSAGES 

  • The Norwegian Knowledge Centre for the Health Services assessed in November 2015 the effectiveness and cost-effectiveness of seven new drugs for the treatment of unresectable or metastatic malignant melanoma in the adult population. Their review included evidence from 17 RCTs.
     
  • For overall survival (over a 2 year time horizon), nivolumab or pembrolizumab as monotherapies as well as the combinations of nivolumab+ipilimumab, 
    vemurafenib+cobimetinib and dabrafenib+trametinib have the highest probabilities of being superior to the other treatment strategies.

     
  • For safety, nivolumab and pembrolizumab have the lowest probability of serious adverse events but the quality of the evidence was rated as low.
     
  • The cost-effectiveness evaluation including all interventions showed that at list prices in Norway, all new treatments had ICERs above € 100 000 per QALY.

 

published on 23-05-2016